Dorothy Gale (Ashanti) is an orphaned teenage girl living in a trailer park in Kansas with her Aunt Em (Queen Latifah) and Uncle Henry (David Alan Grier). Her dream of becoming a singer is slim, but when she overhears that the Muppets are looking for a backup singer, Dorothy hurries to the audition and gives them a demo CD. In returning home, the civil defense sirens sound as a tornado is headed for Dorothy's trailer park. When Aunt Em and Uncle Henry run into the county storm shelter for safety, Dorothy hurries back to her family's mobile home to get Toto, her pet prawn (Bill Barretta). She does not make it out in time, and the two are swept by the tornado across the vast fields of Kansas. When Dorothy climbs out of the wreckage, she finds that Toto can talk and that she is in Munchkinland, part of the vast Land of Oz.The Munchkins and their leader Rizzo (Steve Whitmire) inform Dorothy that the land's ruler the Wizard, has the power to grant her wish of becoming a famous singer. She meets the Good Witch of the North (Eric Jacobson) and receives a pair of magic silver slippers from the Wicked Witch of the East (Eric Jacobson), who was killed when Dorothy's trailer fell on her. Dorothy and Toto embark on a journey on the yellow brick road to meet the Wizard of Oz.On her journey, she meets a Scarecrow (Steve Whitmire), a Tin Thing (David Goelz), and a Cowardly Lion (Eric Jacobson). They are also seeking the Wizard of Oz to give them a brain, heart, and courage, respectively. The group meets various obstacles before arriving at the Emerald City and meeting the Wizard. Before he grants their wishes, the Wizard (Jefferey Tambor of The SpongeBob SquarePants Movie) sends Dorothy and her friends to retrieve the Wicked Witch of the West's magic eye, a tool she uses to see anything she desires in the Land of Oz. Kermit goes to Quentin Tarantino (himself) to ask for advice to stop The Wicked Witch of the West.The Wicked Witch of the West (Eric Jacobson) sees them coming and sends the Flying Monkeys to deal with them. The Witch and the Flying Monkeys capture Dorothy, Toto and Lion while Scarecrow and Tin Thing are dismantled. Toto calls the Munchkins, who set him and Dorothy free and hold up the witch. Dorothy kicks the witch into her own "bottled water bath," which contains tap water (to which she is severely allergic). This causes the Wicked Witch of the West to melt. Dorothy finds the magic eye floating in the tub unharmed and grabs it.Dorothy gains control of the Flying Monkeys and has them rebuild Scarecrow and Tin Thing. Then she and her friends travel back to the Emerald City to have their wishes granted. When they all storm into the Wizard's room, they discover it is merely a Hollywood effects stage and that the Wizard is just an ordinary man. He asked for the witch's eye so that she could not see him for who he really was. Even so, he still proceeds to grant their wishes. Dorothy finally becomes a singer in the Land of Oz, but realizes that all she ever really wanted was to go back home and be with her family. After traveling back to Munchkinland, she meets Glinda the Good Witch of the South (Eric Jacobson and his fourth and final witch role), who tells her that by clicking her heels together three times, she will be able to go anywhere she desires. Saying "take me home to Aunt Em", Dorothy is spun by the slippers' magic into Kansas and finds out that she has been chosen to sing with the Muppets.